US Prescription Spending Could Top $1 Trillion. GLP-1s Lead the WayUS Prescription Spending Could Top $1 Trillion. GLP-1s Lead the WayUS Prescription Spending Could Top $1 Trillion. GLP-1s Lead the Way 

Gemini / GoogleAmericans’ voracious appetite for GLP-1 weight loss drugs has the nation on pace to spend more than $1 trillion on prescription drugs this year, a new report says. U.S. spending on prescription drugs in 2025 jumped nearly 13% to $915 billion and is projected to surpass $1 trillion in 2026, according to the American Society of Health-System Pharmacists (ASHP) report released April 30.